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CSL Behring Associate Scientist, Gene Delivery Technology in Pasadena, California

Associate Scientist, Gene Delivery TechnologyUnited States of AmericaR-0931112012 CSL Behring L.L.C.

Job Description

The Associate Scientist-Gene Therapy Technology will perform cellular and molecular assays to assess gene delivery and gene editing

Responsibilities:

  • Culture of cell lines and primary human cells such as peripheral blood mononuclear cells (PBMC) and hematopoietic stem/progenitor cells (HSPC);

  • Support construction, synthesis and evaluation of polymer-based DNA/RNA/CRISPR delivery vehicles in different disease models;

  • Perform the characterization of physical and chemical properties of gene delivery /gene editing nanoparticles;

  • Carry out flow cytometry, qPCR and RT-qPCR assays to evaluate the efficiency and toxicity of gene delivery and gene editing;

  • Support knock-out or knock-in cell line development activities with gene editing techniques.

  • Present experimental data at departmental or project team meetings.

  • Work as part of a team and independently, perform experimental work and report results.

  • Draft Research Protocols or Standard Operating Procedures (SOP) for the production of gene delivery vectors or generation of cell lines for approval by Scientist and/or Senior Scientist and QA.

  • Perform routine maintenance of scientific instrumentation, as required.

  • Ensure critical instruments are calibrated and calibration records maintained.

  • Ensure that high safety standards are taken into account and adhered to as governed by local, state and federal regulations, laws and policies as well as CSL’s policies and directives.

  • Ordering of reagents and materials.

Essential Qualifications/Experience:

  • BS/MS degree in Life Sciences (Cellular Biology/Molecular Biology), Chemistry, Bioengineering, Chemical engineering or related discipline.

  • Minimum two years hands-on experience in gene delivery or gene editing or related area.

  • Experience with mammalian cell culture and molecular biology techniques and understanding of gene delivery and gene editing is preferred.

  • Experience in gene delivery with polymer or lipid or other materials is preferred.

Essential Skills, Knowledge & Attributes:

  • Ability to multitask and complete work on time.

  • Ability to contribute and work in a cross-functional, multi-disciplinary team environment.

  • Good verbal and written communication skills in English.

  • Well organised, able to plan work appropriately. Attention to detail. Mechanical aptitude and problem-solving skills.

  • Understanding of GLP/GMP regulatory requirements in pharmaceutical drug development.

  • Good working knowledge of Word Processing, Spreadsheets, and general PC familiarity and usage.

  • Understanding of gene therapy concepts and techniques.

  • Experience in culture and maintenance of mammalian cell lines and primary human cells. Experience of isolation, stimulation and extended culture of peripheral blood mononuclear cells (PBMC) and hematopoietic stem/progenitor cells (HSPC) preferred.

  • Experience in gene delivery with polymer or lipid or other methods.

  • Experience in multicolour flow cytometry, DNA sequencing and HPLC.

  • Experience in protein and polymer chemistry.

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State/Province : California

City : Pasadena

Street Address : 129 N. Hill Avenue

Primary Location : CSL Behring Pasadena Lab

Full Time/Part Time : Full Time

Equal Opportunity Employer

CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please click below.

CSL makes all employment decisions without regard to race, color, religion, national origin, ancestry, age, sex, gender, pregnancy, disability, marital status, sexual orientation, gender identity, genetic information, military status, protected veteran status (specifically status as a disabled veteran, recently separated veteran, armed forces service medal veteran, or active duty wartime or campaign badge veteran) or other classification protected by applicable US federal, state or local law. CSL complies with all applicable employment laws, including but not limited to Title VII of the Civil Rights Act of 1964, the Americans with Disabilities Act, the Fair Labor Standards Act, and the Immigration Reform and Control Act. https://www.cslbehring.com/careers/eeo-statement

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